Subject(s)
Humans , Cytokines/classification , Inflammation/drug therapy , Mesoderm/drug effects , Adjuvants, Immunologic , Arthritis, Rheumatoid/immunology , Autoantibodies , Cytokines/antagonists & inhibitors , Cytokines/immunology , Interleukin-1/immunology , Interleukin-1/pharmacology , Interleukin-6/immunology , Interleukin-6/pharmacology , Receptors, Cytokine/immunology , Transforming Growth Factor beta/immunology , Transforming Growth Factor beta/pharmacology , Tumor Necrosis Factor-alpha/immunology , Tumor Necrosis Factor-alpha/pharmacologyABSTRACT
Isomers of fibroblast growth factor and members of the transforming growth factor beta family have been identified as potent mesoderm inducing factors, particularly in amphibians. Activins belonging to the latter group are capable of inducing all types of mesoderm. Inhibins, also belonging to the same family of proteins have an exactly opposite biological action than activins in the adult organism. We have examined the effects of human seminal plasma inhibin on the early development of the chick embryo, where also activins appear to be important in mesoderm induction. Contrary to expectations, inhibin brought about stimulation of development of somites and heart, structures of mesodermal origin, and increase in the body length in more than 50% of the treated chick blastoderms. A synthetic fragment of human seminal plasma inhibin, a nonapeptide fragment of C-terminal end, also exhibited similar effects. In some cases the treatments resulted in completely abnormal development while in some increase in the number of somites was associated with abnormality in the anterior region. Our results demonstrate that human seminal plasma inhibin does not act as an inhibitor of mesoderm induction in the chick embryo but in amniotes inhibin-related molecules may have a role as mesoderm enhancers.
Subject(s)
Amino Acid Sequence , Animals , Chick Embryo , Humans , Inhibins/chemistry , Male , Mesoderm/drug effects , Molecular Sequence Data , Oligopeptides/pharmacology , Peptide Fragments/pharmacology , Semen/chemistryABSTRACT
45 male albino rats were used to study the effect of deep submucosal implantation of DMBA on lingual carcinogenesis. The results showed development of different mesenchymal neoplasm [fibroma, fibrosarcoma and leiomyosarcoma]. So, this method of implantation could not be used as an ideal animal model for production of single known neoplasm as had been investigated by many investigators before